Abstrato

Tyrosine kinase inhibition in neurodegeneration and carcinogenesis

Charbel Hebron

 There are a number of diseases, including cancer and neurodegeneration that have different mechanisms of action but might have similar therapeutic targets. In order to speed up the removal of undesired oncogenes and prevent the buildup of toxic proteins in cancer and neurodegeneration, respectively, autophagy can be used as a quality control mechanism that is shared by mitotic and post-mitotic cells. Tyrosine kinase inhibition can cause autophagy, which results in normal cell survival, and is a therapeutically useful technique. This article sheds light on how tyrosine kinase inhibition is therapeutically utilised to stop tumour development and mitotic cell division, and it may also help post-mitotic neurons survive in cases of dementia. A collection of hereditary and sporadic conditions known as neurodegenerative diseases are characterised by gradual nervous system failure and neuronal death. In addition to being a group of connected genetic illnesses, cancer is characterised by cells that start dividing uncontrollably and spread to neighbouring tissues.