Abstrato

Antiproliferative and cytotoxic effects of cardiac glycosides

Verdick Jacob

Cardiac glycosides are a class of natural compounds with diverse biological activities, including antiproliferative and cytotoxic effects. This abstract summarizes recent research on the potential therapeutic applications of cardiac glycosides in cancer treatment. Studies have revealed their ability to inhibit cell proliferation and induce cell death in various cancer cell lines. Mechanistically, cardiac glycosides target key signaling pathways involved in cancer progression, such as the Na+/K+-ATPase pump and the Wnt/β-catenin pathway. Moreover, they have shown synergistic effects with conventional chemotherapeutic agents, suggesting their potential use as adjuvants in combination therapies. These findings highlight the promising role of cardiac glycosides as novel anticancer agents and warrant further investigation to unlock their full therapeutic potential