Abstrato

Upregulation of SOCS1 and SOCS3 mRNA levels in pediatric patients with henoch-schoenlein purpura

Fengying Wang, Lusheng Huang, Kang Xu, Yufang Yuan, Zhaofang Tian, Lijuan Yang

Suppressors of Cytokine Signaling (SOCS) family members are inhibitors of cytokine signaling pathways. Emerging evidence suggests the involvement of SOCS1 and SOCS3 in a variety of diseases, including allergy, autoimmune diseases, and inflammation. This study aimed to investigate the expression of SOCS1 and SOCS3 in the development of Henoch-Schoenlein Purpura (HSP) in children. Peripheral Blood Mononuclear Cells (PBMC) were isolated from children with HSP (HSP group, n=20) and healthy children (control group, n=15). The mRNA levels of SOCS1 and SOCS3 in PMBC were detected by Real Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR). The results showed that the mRNA levels of SOCS1/3 were up-regulated in HSP group compared to control group (P<0.01). These data suggest that SOCS1 and SOCS3 mRNA levels are upregulated in children with HSP.