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The Link between vitamin D, miRNA and multiple sclerosis

Eiman M Mohammed

Multiple sclerosis (MS) is a complex autoimmune disease that poses a challenge to the medical field. To our current knowledge, MS is a disease with predisposing genetic variants and environmental influencers. Environmental factors may influence disease pathology through different mechanisms, one of which the author proposes to be microRNAs. microRNA (miRNA) are small non-coding RNA molecules with a size of approximately 22 nucleotides, involved in post-transcriptional regulation of genes. Vitamin D deficiency is an established risk factor for MS pathogenesis. The relation between vitamin  D and miRNA may shed the light on the effect of vitamin D on MS pathology. Available data on vitamin D-miRNA-MS seems encouraging, though the data reproducibility has been a major limiting factor.