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The expressions and roles of S100A6 and S100A10 in gastric cancer

Chunmei Li, Yanhong Hou, Jing Zhang, Lin Zhang

Aim: S100A6 and S100A10 genes are upregulated in many human malignant tumors. But, little is known about their expressions or roles in gastric adenocarcinoma. In the present study, we intended to investigate the expressions and clinicopathologic significance of the two genes in gastric adenocarcinoma.

Methods: The immunohistochemical assays were performed to detect the expressions of S100A6 and S100A10 in 62 specimens and their correlation with clinicopathologic features was examined.

Results: In all 62 gastric adenocarcinoma specimens, 27 (43.5%) and 20 (32.3%) had a strong expression of S100A6 and S100A10. In the adenocarcinoma specimens with a strong S100A6 expression, the proportion of poorly differentiated adenocarcinomas was significantly higher than that in specimens with a weak S100A6 expression (P<0.05). The proportions of lymph node metastasis and the depth of the tumors in the specimens with a strong S100A6 or S100A10 expression were higher significantly too. The results of survival analysis showed that the prognosis of patients whose specimens had a strong S100A6 expression was poorer than that of patients with a weak expression significantly (P<0.05).

Conclusions: The expressions of S100A6 and S100A10 could be correlated with poor differentiation and metastasis of gastric adenocarcinoma. In some distance, S100A6 may be considered a potential marker for gastric adenocarcinoma with prognostic value.