Abstrato

The evolution of breast cancer's molecular pathology

Anuvya Prare

The current hypothesis for the progression of human breast cancer proposes a multi-stage linear process starting with Flat Epithelial Atypia (FEA), moving on to Atypical Ductal Hyperplasia (ADH), developing into DCIS, and finally reaching the potentially fatal stage of invasive ductal carcinoma. Finding the molecular changes linked to the various stages of breast cancer growth has long been a difficult task for researchers studying human breast cancer. The inability to use cutting-edge molecular technology on the microscopic pre-invasive stages of breast carcinogenesis has hindered progress towards this goal up until recently.