Revista de Pesquisa em Virologia


The Effect of Ezetimibe in the Treatment of Ebola.

Ali Khanifar

In this article, we are looking for treatment for Ebolavirus.We will do it using a cholesterol-lowering drug called Ezetimibe.Marburg and Ebola hemorrhagic fevers are severe, systemic viral diseases affecting humans and non-human primates. They are characterized by multiple symptoms such as hemorrhages, fever, headache, muscle and abdominal pain, chills, sore throat, nausea, vomiting and diarrhea. Elevated liver-associated enzyme levels and coagulopathy are also associated with these diseases. Marburg and Ebola hemorrhagic fevers are caused by (Lake victoria) Marburg virus and different species of Ebola viruses, respectively. They are enveloped, single-stranded RNA viruses and belong to the family of filoviridae. Case fatality rates of filovirus disease outbreaks are among the highest reported for any human pathogen, ranging from 25 to 90% or more. But when Ezetimibe is given to patients with the Ebola virus, we see that the drug blocks the transmission of the virus to the body by delivering the virus to the immune system.Ezetimibe has a higher affinity for NPC1L1 receptor than cholesterol, and cholesterol has a higher affinity for NPC1L1 receptor than Ebola virus . In fact, if we want to show the percentage of desire for NPC1L1 receptor, it is as follows: Ezetimibe> Cholesterol> Ebola virus