Revista de Pesquisa em Virologia


Prevalence of chronic hepatitis B virus infection in patients with nucleotide analogue

Huang Niu

The current available agents for the treatment of chronic hepatitis B (CHB) incorporate immunomodulatory operators, such as interferon-? and pegylated interferon-?, and verbal nucleoside/nucleotide analogs (NAs), counting lamivudine, adefovir, telbivudine, entecavir and tenofovir. The NAs work basically by restraining hepatitis B infection (HBV) DNA polymerase movement and hence stifle HBV replication. Verbal NAs have ended up the pillar of CHB treatment, primarily due to their significant viral suppressive impacts conjointly due in portion to the ease of single every day dosing and need of noteworthy side impacts. One major disadvantage of NA treatment is the advancement of sedate resistance transformations with long-term treatment. Lamivudine, the primary verbal NA endorsed for CHB patients, is related with tall rates of medicate resistance, with resultant virological backslide and biochemical flare. Luckily, more up to date and stronger NAs, such as entecavir and tenofovir, have exceptionally moo resistance rates, with strong and tough viral suppression.