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miR-499 rs3746444 polymorphism and coronary artery disease risk: a meta-analysis

Fanbo Meng, Xudong Guo, Wei Wang, Baisong Lin

Background: Some studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of Coronary Artery Disease (CAD). However, the results were still unclear. Therefore, we conducted a meta-analysis.

Method: An electronic literature search was conducted using the following database: PubMed, Embase and China National Knowledge Infrastructure (CNKI) till to June 2017. The strength of association was investigated by pooling Odds Ratio (OR) with its corresponding 95% Confidence Interval (CI).

Results: In total, four studies with 2642 cases and 2260 controls were included in this meta-analysis. MiR-499 rs3746444 polymorphism was significantly associated with an increased risk of CAD (OR=1.30; 95% CI, 1.00-1.69). In the race subgroup analysis, Asians with miR-499 rs3746444 polymorphism did not show increased CAD risk (OR=1.25; 95%CI, 0.89-1.76). In the subgroup analysis according to source of control, hospital-based studied showed significantly association (OR=1.44; 95% CI, 1.11-1.86).

Conclusion: In conclusion, this meta-analysis suggests that miR-499 rs3746444 polymorphism was associated with CAD risk.