Abstrato

Improving the understanding about Immune Profile before the HELLP Syndrome Onset: A Case Report

LMS Dusse*, PN Alpoim, AC Campi-Azevedo, FS Mendes, EM Lage, PG Teixeira, JGA Coelho-dos-Reis, A Teixeira-Carvalho and OA Martins-Filho

The term HELLP refers to the acronym characterized by Hemolysis, Elevated Liver enzymes and Low Platelets count. The aim of this study was to evaluate the immune profile of a pregnant woman that later developed HELLP syndrome in comparison to gestational age-matching healthy pregnant. We have determined multiple plasma biomarkers, including chemokines, pro-inflammatory/regulatory cytokines and growth factors in a pregnant woman (19th+4 week of gestation) 12 days before HELLP syndrome onset. An overproduction of CXCL10, CCL2, CCL11, CXCL8, IFN-? and IL-13, besides a pronounced deficiency of IL-6, G-CSF, IL-5, IL-10 and IL-12 was obtained in the studied pregnant woman comparing to controls. Our pioneer findings of pro-inflammatory increasing and insufficient regulatory mediators may support future strategies to clarify the early events associated with the HELLP syndrome pathophysiology. Furthermore, these data could be a powerful tool for providing disease early biomarkers, as well as perspectives for precise therapeutic intervention