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Glyphosate exposure modulates the expression of c-jun, ikkb and NFκappaβ mRNA expression in skeletal muscle of male Wistar rats

Sangaraju Soumya Sri, Kavitha S, Selvaraj J, V Vishnupriya, Gayathri R

Diabetes is a metabolic disorder and Nuclear Factor κappaβ (NF-κβ) plays a key role in the pathogenesis of diabetes. Glyphosate is a herbicide and crop desiccant, it is used to kill weeds and grasses that compete with crops. c-jun is an important component of AP-1 it gives an early response transcriptional factor that regulates the expression of a diverse range of genes. To study the effect of glyphosate exposure on the expression of c-jun, IKKB, and NF-kappaB mRNA expression in skeletal muscle of male Wistar rat. The present study suggests that glyphosate exposure to animals caused a significant increase in the expression of inflammatory signaling molecules in skeletal muscle indicating that glyphosate induces diabetes by activating inflammatory signaling in a dose-dependent manner.