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GABAergic Transmission and Inhibitory Postsynaptic Potentials: Implications for Neurological Disorders

Ricky Wang

The gamma-amino butyric acid (GABA) system, as one of the major inhibitory neurotransmitter systems in the central nervous system (CNS), plays a critical role in regulating neural activity and maintaining the balance between excitation and inhibition. GABAergic transmission, mediated by GABA receptors, leads to inhibitory postsynaptic potentials (IPSPs) that contribute to shaping neural circuits and network dynamics. Dysfunction of GABAergic transmission and alterations in IPSPs has been implicated in various neurological disorders, providing important insights into the pathophysiology and potential therapeutic targets for these conditions