Abstrato

Expressions and significance of tumor suppressor gene PTEN and p53 in prostate cancer

Wei Lu, Jia-Qiang Wang, Yu-Hong Zhang, Yong Wang, Wen-Jing Yin, Jian-Min Guo, Yi Li, Yan-Min Wang, Ji-Hu Lian, Ying-Yuan Gao, Xiao-Ran Wang, Bing-Chen Liu

The study aim was to investigate the impacts of the expressions of tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten (PTEN) and p53 on the grading and prognosis of prostate cancer. Immunohistochemistry was used to detect the expressions of tumor suppressor gene PTEN and p53 in 80 prostate cancer and adjacent tissue samples, as well as in 40 normal tissue samples, and the relationships among their expressions, prostate cancer grading, and prognosis were then compared. p53 was significantly up-regulated in prostate cancer tissue (P<0.05), but PTEN was significantly down-regulated (P<0.05). The expression levels of PTEN in the cancer tissues with different differentiation degrees, stages, metastasis, and prognosis exhibited significant differences (P<0.05). The expression levels of p53 in the cancer tissues with different differentiation degrees and prognosis exhibited significant differences (P<0.05). There were no correlations between the expressions of p53 and PTEN (P>0.05). Apoptosis-related gene p53 and PTEN participate in the grading of prostate cancer, and also affect patient’s prognosis, but there are no correlations between these two genes.