Abstrato

Expression and clinical significance of AXL and NEK2 genes in oral squamous cell carcinoma (OSCC)

Chengyong Wang, Chuanqing Mao, Yongzhen Lai, Weihui Chen

Objective: To detect AXL (Anexelekto) and Nek2 (never in mitosis A, NIMA-related kinase 2) genes in the Oral Squamous Cell Carcinoma (OSCC) and analyse their expressions.

Methods: For the included 36 cases with OSCC selected by our hospital, the immunohistochemical assay was used to detect Axl of carcinoma tissues and corresponding para-carcinoma tissues (para-carcinoma group) and PCR technology was adopted to analyse expressions of AXL and NEK2 genes.

Results: NEK2 mRNA was highly expressed in the carcinoma tissue, and differences among groups at differentiated degrees and different clinical phases were significant (P<0.05). The positive expression rate of Axl in OSCC tissue (63.9%) was higher than that of para-carcinoma normal tissue (22.2%), showing significant differences (P<0.05).

Conclusions: Expression of AXL and NEK2 genes in oral cancer cell strain was higher than that in normal oral epithelium cell.