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Evaluation of the severity of liver cirrhosis using b values based magnetic resonance diffusion weighted imaging of liver lobe

Zhenyu Shu, Xiangyang Gong, Songhua Fang, Dewang Mao, Jie Zheng, Jianguo Xu, Qiong Song, Yueqiao Zhang

This study aimed to investigate the correlation of magnetic resonance diffusion weighted imaging of liver lobe and Child-Pugh classification in Chinese patients with liver cirrhosis. 72 liver cirrhosis patients and 23 healthy volunteers were enrolled, and patients were divided into class A, B, C according to Child- Pugh classification. All subjects received diffusion weighted imaging with b values set as 0, 400, 600 and 800 s/mm². The correlation between ADC values of different lobes and Child-Pugh classification was analyzed. ADC values were significantly lower in patients with liver cirrhosis than in healthy controls. Moreover, ADC value was negatively correlated with Child-Pugh classification. At b value of 400 s/mm2 ADC value of left liver lobe was the best indicator to distinguish normal liver from liver cirrhosis and the area under the ROC curve was 0.914. At b value of 600 s/mm² ADC value of right liver lobe was the best indicator to distinguish class A from class B-C of liver cirrhosis and the area under the ROC curve was 0.834. ADC value of right liver lobe was also the best indicator to distinguish class A-B from class C of liver cirrhosis and the area under the ROC curve was 0.884. These data indicate that ADC value of liver lobe is correlated with liver cirrhosis severity determined by Child-Pugh classification and is a new noninvasive indicator of the severity of liver cirrhosis.