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Effects of PPARγ agonist decreasing the IL-1β, IL-6 and TNF-α content in rats on focal cerebral ischemia-reperfusion injury

Qiuju Li, Yancang Liu, Lei Chen

Objective: To observe the protective effects of PPARγ Pioglitazone agonist on the focal cerebral Ischemia-Reperfusion injury (I/ R) and explore its mechanism of action.

Methods: By duplicating the rat Middle Cerebral Artery Block Model of Reperfusion (MCAO/R), respectively by TTC staining method, neural function scoring method to observe the effect of the PPARγ agonist on cerebral infarction volume and behavioral score in rats. And observe the effects of PPARγ agonist on the IL-1β, IL-6 and TNF-α content in rats with brain tissue.

Results: PPARγ agonists are able to reduce the volume and behavior of cerebral infarction in I/R rats and decrease the content of IL-1β (t=7.84, P<0.05), IL-6 (t=5.23, P<0.05) and TNF-α (t=8.41, P<0.05) in brain tissues.

Conclusion: PPARγ agonist has a protective effect on cerebral ischemia reperfusion injury in rats, and its mechanism is related to decreased IL-1β, IL-6 and TNF-α in brain tissues.