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Association of vascular endothelial growth factor polymorphisms with preeclampsia risk in pregnant women

Yuling Tian, Huili Yang, Shuxia Yao, Huajie Zhai, Shuyi Han

Objective: To investigate the relationship between VEGF SNPs+936C/T, -634G/C, -2578C/A, -1154G/A and risk of Preeclampsia (PE).

Methods: A total of 108 cases and 108 normal pregnant women as control in a Chinese population. Polymerase Chain Reaction (PCR) amplification of the genes and sequencing methods were used to genotyping VEGF SNPs +936C/T, -634G/C, -2578C/A and -1154G/A.

Results: Alleles and genotypes of VEGF -634G/C, -2578C/A and -1154G/A showed no statistical significant difference between PE patients group and the control group (P>0.05), while VEGF +936C/T TT genotype and T allele frequencies were significantly higher than those with the CC genotype, OR value were 1.68 (1.17-2.24) and 1.32 (1.09-1.69). Conditional logistic regression analysis showed that +936C/T TT genotype and T allele had no statistical significance with environmental related factors.

Conclusions: We observed that the VEGF +936C/T TT genotype and T allele were associated with the risk of preeclampsia for gestations in Chinese pregnant women. More studies with larger sample size, better design, and using detailed patient records need to be conducted.