Abstrato

Association between apolipoprotein E gene and heart blood stasis syndrome in premature coronary heart disease pedigrees within the Hunan han nation population

Jie Li, Ling-Li Chen, Jian-Guo Wang, Zhi-Xi Hu, Yue Chen, Xiang-Zhuo Zhang, Xue-Qin Zeng, Jun-Peng Zhou

Background: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, polymorphisms in the apoE gene have been associated with an increased relative risk of coronary artery disease (CAD).

Objective: To determine whether or not the apoE gene increases the risk of heart blood stasis syndrome (HBSS) in premature coronary heart disease (PCHD) pedigrees.

Methods: Twenty-eight core pedigrees with PCHD and HBSS were collected. The apoEε2/ε3/ε4 genotype was measured using a PCR-RFLP technique. HHRR and TDT were used with core pedigrees based on the result that the apoE polymorphism was linked with PCHD.

Results: According to HHRR, the apoE ε4 allele may be associated with PCHD with HBSS (P<0.05). According to the TDT test, the susceptibility loci of CHD with HBSS may be linked to the apoE ε4 allele (P<0.01).

Conclusions: The apoE ε4 gene polymorphism in PCHD and HBSS pedigrees associated with coronary heart disease, and coronary heart disease susceptibility loci may be linked with apoE ε4 alleles, which indicates that the apoE gene may be linked to the susceptibility location of HBSS in CHD within the Hunan han nation population.