Abstrato

A meta-summary and bioinformatic analysis of biomarkers kidney tubule disease.

Sundaram

Increasing interstitial fibrosis and tubular atrophy indicate the progression of renal parenchyma injury, regardless of the underlying cause. The gold standard for identifying the presence and degree of tubulointerstitial scarring is still histopathologic evaluation of renal tissue obtained by biopsy. The goal of a significant multimodal effort by researchers in the renal community and beyond has been the discovery of reliable non-invasive methods for taking a snapshot and for longitudinal monitoring of parenchymal deterioration. The development and assessment of tissue and biofluid assays for novel analytes with potential application to the diagnosis and prognosis of kidney disease have been fostered by research in this area that has utilized in vitro and in vivo experimental models. Here, we review current developments in the hunt for "biomarkers" for detection.